Allogenic versus autologous bone filled cages for cervical spondylotic myelopathy

doi:10.3969/j.issn.2095-4344.2015.03.001

Abstract

Abstract:

BACKGROUND: There are many filling materials used in anterior cervical fusion. Autogenous bone and allograft bone account for a large proportion; however, autogenous bone induces many complications such as hemorrhage, infection and postoperative pain in the donor bone region, which has been attracted attentions gradually. Allogeneic bone with good biocompatibility and safety can be used as a kind of ideal fusion filling material.

OBJECTIVE: To compare the clinical efficacy of autogenous bone or allograft bone filled cage combined with steel plate in the anterior cervical fusion.
METHODS: A total of 44 patients (44 segments) with cervical spondylotic myelopathy underwent anterior cervical discectomy, interbody fusion combined with steel plate fixation from January 2012 to June 2013. An oblique anterior cervical incision, 2.5-3.0 cm, was made. The intervertebral disc and posterior longitudinal ligament were cut and the endplate was tried to be reserved. Then, the iliac bone from 24 cases was obtained for the interbody fusion, and allogeneic bone was used in 20 cases. Clinical efficacy was assessed with X-ray, Japanese Orthopaedic Association (JOA) grade and Odom’s evaluation scale.

RESULTS AND CONCLUSION: All patients acquired the follow-up of 12-18 months, and there were no significant differences between the two groups in the postoperative complications and JOA score. The excellent and good rate (Odom’s standard) was significantly higher in the allogeneic bone group than the autogenous bone group (P < 0.05). After 3 and 6 months, the fusion rates in the allogeneic bone group were lower than those in the autogenous bone group, and the fusion rates of two groups were 100% after 12 months. Imaging studies revealed that at 3, 6, 12 months after operation, there were no differences between the two groups in the intervertebral height and Cobb’s angle (P > 0.05). These findings indicate that allogeneic bone has a fusion rate similar to the autogenous iliac bone in the treatment of cervical spondylotic myelopathy, and it also can maintain the cervical physiological curvature and help to restore the intervertebral height, which is considered as an ideal bone filling material for anterior cervical fusion.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: Cervical Vertebrae, Spinal Fusion, Transplantation, Autologous, Internal Fixators

CLC Number:

R318

Sun Jia-jia, Yang Hui-lin, Zhou Jun, Zhang Bin, Zhang Kai. Allogenic versus autologous bone filled cages for cervical spondylotic myelopathy[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(3): 329-334.

Figures/Tables 3

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